2026-04-29T12:23:11Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/176032024-09-21T19:35:11Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Baglietto-Vargas, David author Prieto, Gilberto Aleph author Limon, Agenor author Forner, Stefania author Rodriguez-Ortiz, Carlos J author Ikemura, Kenji author Ager, Rahasson R author Medeiros, Rodrigo author Trujillo-Estrada, Laura author Martini, Alessandra C author Kitazawa, Masashi author Davila, Jose C author Cotman, Carl W author Gutierrez, Antonia author LaFerla, Frank M author 2018-06-06 Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, although the molecular and cellular mechanisms underlying these defects remain to be elucidated. Determining the timing and nature of the early synaptic deficits is critical for understanding the progression of the disease and for identifying effective targets for therapeutic intervention. Using single-synapse functional and morphological analyses, we find that AMPA signaling, which mediates fast glutamatergic synaptic transmission in the central nervous system (CNS), is compromised early in the disease course in an AD mouse model. The decline in AMPA signaling is associated with changes in actin cytoskeleton integrity, which alters the number and the structure of dendritic spines. AMPA dysfunction and spine alteration correlate with the presence of soluble but not insoluble Aβ and tau species. In particular, we demonstrate that these synaptic impairments can be mitigated by Aβ immunotherapy. Together, our data suggest that alterations in AMPA signaling and cytoskeletal processes occur early in AD. Most important, these deficits are prevented by Aβ immunotherapy, suggesting that existing therapies, if administered earlier, could confer functional benefits. 10.1111/acel.12791 1474-9726 Aging cell http://hdl.handle.net/10668/12558 29877034 http://hdl.handle.net/20.500.12105/17603 AMPA receptor Alzheimer's disease Aβ actin cytoskeleton immunotherapy synaptic impairment Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.