2026-05-22T00:57:29Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/176012024-09-21T23:07:18Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16987

00925njm 22002777a 4500 dc Palau-Rodriguez, Magali author Tulipani, Sara author Marco-Ramell, Anna author Miñarro, Antonio author Jáuregui, Olga author Sanchez-Pla, Alex author Ramos-Molina, Bruno author Tinahones, Francisco J author Andres-Lacueva, Cristina author 2018-06-01 Bariatric surgery is considered the most efficient treatment for morbid obesity and its related diseases. However, its role as a metabolic modifier is not well understood. We aimed to determine biosignatures of response to bariatric surgery and elucidate short-term metabolic adaptations. We used a LC- and FIA-ESI-MS/MS approach to quantify acylcarnitines, (lyso)phosphatidylcholines, sphingomyelins, amino acids, biogenic amines and hexoses in serum samples of subjects with morbid obesity (n = 39) before and 1, 3 and 6 months after bariatric surgery. K-means cluster analysis allowed to distinguish metabotypes of response to bariatric surgery. For the first time, global metabolic changes following bariatric surgery independent of the baseline health status of the subjects have been revealed. We identify two metabolic phenotypes (metabotypes) at the interval 6 months-baseline after surgery, which presented differences in the levels of compounds of urea metabolism, gluconeogenic precursors and (lyso)phospholipid particles. Clinically, metabotypes were different in terms of the degree of improvement in insulin resistance, cholesterol, low-density lipoproteins and uric acid independent of the magnitude of weight loss. This study opens new perspectives and new hypotheses on the metabolic benefits of bariatric surgery and understanding of the biology of obesity and its associated diseases. 10.1371/journal.pone.0198214 1932-6203 PloS one http://hdl.handle.net/10668/12528 29856816 http://hdl.handle.net/20.500.12105/17601 Metabotypes of response to bariatric surgery independent of the magnitude of weight loss.