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00925njm 22002777a 4500 dc Maldonado-Araque, Cristina author Valdés, Sergio author Lago-Sampedro, Ana author Lillo-Muñoz, Juan Antonio author Garcia-Fuentes, Eduardo author Perez-Valero, Vidal author Gutierrez-Repiso, Carolina author Goday, Albert author Urrutia, Ines author Peláez, Laura author Calle-Pascual, Alfonso author Castaño, Luis author Castell, Contxa author Delgado, Elias author Menendez, Edelmiro author Franch-Nadal, Josep author Gaztambide, Sonia author Girbés, Joan author Ortega, Emilio author Vendrell, Joan author Chacón, Matilde R author Chaves, Felipe J author Soriguer, Federico author Rojo-Martínez, Gemma author 2018-04-26 Previous studies have suggested that iron deficiency (ID) may impair thyroid hormone metabolism, however replication in wide samples of the general adult population has not been performed. We studied 3846 individuals free of thyroid disease, participants in a national, cross sectional, population based study representative of the Spanish adult population. Thyroid stimulating hormone (TSH), free thyroxin (FT4) and free triiodothyronine (FT3) were analyzed by electrochemiluminescence (E170, Roche Diagnostics). Serum ferritin was analyzed by immunochemiluminescence (Architect I2000, Abbott Laboratories). As ferritin levels decreased (>100, 30-100, 15-30, 100, 30-100, 15-30, 10.1038/s41598-018-24352-9 2045-2322 Scientific reports http://hdl.handle.net/10668/12403 29700318 http://hdl.handle.net/20.500.12105/17592 Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study.