2026-06-14T03:42:05Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/175832024-09-21T20:38:36Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Villatoro, Antonio J author Claros, Silvia author Fernández, Viviana author Alcoholado, Cristina author Fariñas, Fernando author Moreno, Antonio author Becerra, José author Andrades, José A author 2018-03-27 Feline eosinophilic keratitis (FEK) is a chronic keratopathy caused by a suspected immune mediated response to an unknown antigenic stimulus. The purpose of this study was to investigate the safety and therapeutic effects of allogeneic feline adipose-derived mesenchymal stromal cells (fAd-MSCs) implanted subconjunctival around the ocular surface lesion in five cats with FEK refractory to current available treatments. FEK was diagnosed by clinical appearance and evidence of eosinophil and/or mast cells in corneal cytology. Each animal was treated with two applications of 2 × 106 million of fAd-MSCs 2 months apart. Ocular surface integrity was assessed before treatment and at 1, 3, 6 and 11 months after treatment. Clinical signs showed a significant change during the follow-up with resolution of the corneal and conjunctiva lesions and there were no signs of regression or worsening. Implanted cells were well-tolerated and effective reducing clinical signs of FEK with a sustained effect during the study period. None of the animals showed systemic or local complications during the study. To our knowledge, this is the first time in literature that local implantation of allogeneic fAd-MSCs has been found as an effective therapeutic alternative to treat cats with FEK. 10.1186/s12917-018-1413-4 1746-6148 BMC veterinary research http://hdl.handle.net/10668/12281 29587744 http://hdl.handle.net/20.500.12105/17583 Adipose mesenchymal stem cell Allogeneic cell therapy Cat Feline eosinophilic keratitis Feline herpes virus Lacrimal gland Safety and efficacy of the mesenchymal stem cell in feline eosinophilic keratitis treatment.