2026-04-29T04:52:11Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/175752024-09-21T23:01:27Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Serena, Carolina author Ceperuelo-Mallafré, Victoria author Keiran, Noelia author Queipo-Ortuño, Maria Isabel author Bernal, Rosa author Gomez-Huelgas, Ricardo author Urpi-Sarda, Mireia author Sabater, Mónica author Pérez-Brocal, Vicente author Andrés-Lacueva, Cristina author Moya, Andres author Tinahones, Francisco J author Fernández-Real, Jose Manuel author Vendrell, Joan author Fernández-Veledo, Sonia 2024-02-08T14:41:02Z 2024-02-08T14:41:02Z 2018-02-12 http://hdl.handle.net/10668/12118 http://hdl.handle.net/20.500.12105/17575 29434314 10.1038/s41396-018-0068-2 1751-7370 The ISME journal Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects. Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism. This increase was associated with specific changes in gut microbiota related to succinate metabolism: a higher relative abundance of succinate-producing Prevotellaceae (P) and Veillonellaceae (V), and a lower relative abundance of succinate-consuming Odoribacteraceae (O) and Clostridaceae (C) in obese individuals, with the (P + V/O + C) ratio being a main determinant of plasma succinate. Weight loss intervention decreased (P + V/O + C) ratio coincident with the reduction in circulating succinate. In the spontaneous evolution after good dietary advice, alterations in circulating succinate levels were linked to specific metagenomic signatures associated with carbohydrate metabolism and energy production with independence of body weight change. Our data support the importance of microbe-microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk. eng Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota. research article