2026-04-30T06:56:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/175432024-11-29T20:49:41Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Theurillat, Jean-Philippe
author
Metzler, Stefan Christian
author
Henzi, Nico
author
Djouder, Nabil
author
Helbling, Marianne
author
Zimmermann, Anna-Kathrin
author
Jacob, Francis
author
Soltermann, Alex
author
Caduff, Rosmarie
author
Heinzelmann-Schwarz, Viola
author
Moch, Holger
author
Krek, Wilhelm
funder
Gertrud-Hagmann-Stiftung fur Malignomforschung
funder
Swiss Cancer League
funder
Julius Muller Stiftung zur Unterstutzung der Krebsforschung
2024-02-08T11:55:05Z
2024-02-08T11:55:05Z
2011-03-08
Cancer Cell. 2011;19(3):317-32.
10.1016/j.ccr.2011.01.019
1878-3686
Cancer cell
21397856
http://hdl.handle.net/20.500.12105/17543
Abrogation of negative feedback control represents a fundamental requirement for aberrantly activated signaling pathways to promote malignant transformation and resistance to therapy. Here we identify URI, which encodes a mitochondrial inhibitor of PP1γ and PP1γ-mediated feedback inhibition of S6K1-BAD survival signaling, as an oncogene amplified and overexpressed in ovarian cancer cell lines and human ovarian carcinomas. URI is an "addicting" oncogene selectively required for the survival of ovarian cancer cells with increased URI copy number. By constitutively detaining PP1γ in inactive complexes, URI sustains S6K1 survival signaling under growth factor-limiting conditions and mediates resistance of cells to cisplatin. Thus, oncogenic activation of URI defines an important mechanism for activating mitochondrial S6K1-BAD signaling and promoting cell survival through disabling PP1γ-dependent negative feedback inhibition.
eng
URI is an oncogene amplified in ovarian cancer cells and is required for their survival.
journal article
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URL
https://repisalud.isciii.es/bitstreams/14073e2d-5564-4ad4-a4ad-7d82b9e3931e/download
File
MD5
044ac4a9a3893bddecea4eda716ec24f
2658021
application/pdf
URIIsAnOncogeneAmplified_2011.pdf
URL
https://repisalud.isciii.es/bitstreams/ab61eee6-3ba8-4aec-8613-afb81e6920ae/download
File
MD5
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text/plain
URIIsAnOncogeneAmplified_2011.pdf.txt