2026-04-29T23:12:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/175342024-11-29T18:07:07Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Hernández-Barranco, Alberto
author
Santos, Vanesa
author
Mazariegos, Marina S
author
Caleiras, Eduardo
author
Nogués, Laura
author
Mourcin, Frédéric
author
Léonard, Simon
author
Oblet, Christelle
author
Genebrier, Steve
author
Rossille, Delphine
author
Benguría, Alberto
author
Sanz, Alba
author
Vázquez, Enrique
author
Dopazo, Ana
author
Efeyan, Alejo
author
Ortega-Molina, Ana
author
Cogne, Michel
author
Tarte, Karin
author
Peinado Selgas, Hector
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Fundación La Caixa
funder
Instituto de Salud Carlos III
2024-02-07T11:20:54Z
2024-02-07T11:20:54Z
2024-01-30
Cell Rep . 2024 :113705.
10.1016/j.celrep.2024.113705
2211-1247
Cell reports
38307025
http://hdl.handle.net/20.500.12105/17534
Nerve growth factor receptor (NGFR) is expressed by follicular dendritic cells (FDCs). However, the role of NGFR in the humoral response is not well defined. Here, we study the effect of Ngfr loss on lymph node organization and function, demonstrating that Ngfr depletion leads to spontaneous germinal center (GC) formation and an expansion of the GC B cell compartment. In accordance with this effect, stromal cells are altered in Ngfr-/- mice with a higher frequency of FDCs, characterized by CD21/35, MAdCAM-1, and VCAM-1 overexpression. GCs are located ectopically in Ngfr-/- mice, with lost polarization together with impaired high-affinity antibody production and an increase in circulating autoantibodies. We observe higher levels of autoantibodies in Bcl2 Tg/Ngfr-/- mice, concomitant with a higher incidence of autoimmunity and lower overall survival. Our work shows that NGFR is involved in maintaining GC structure and function, participating in GC activation, antibody production, and immune tolerance.
eng
NGFR regulates stromal cell activation in germinal centers.
journal article
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