2026-04-29T23:12:19Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/175342024-11-29T18:07:07Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Hernández-Barranco, Alberto author Santos, Vanesa author Mazariegos, Marina S author Caleiras, Eduardo author Nogués, Laura author Mourcin, Frédéric author Léonard, Simon author Oblet, Christelle author Genebrier, Steve author Rossille, Delphine author Benguría, Alberto author Sanz, Alba author Vázquez, Enrique author Dopazo, Ana author Efeyan, Alejo author Ortega-Molina, Ana author Cogne, Michel author Tarte, Karin author Peinado Selgas, Hector author 2024-01-30 Nerve growth factor receptor (NGFR) is expressed by follicular dendritic cells (FDCs). However, the role of NGFR in the humoral response is not well defined. Here, we study the effect of Ngfr loss on lymph node organization and function, demonstrating that Ngfr depletion leads to spontaneous germinal center (GC) formation and an expansion of the GC B cell compartment. In accordance with this effect, stromal cells are altered in Ngfr-/- mice with a higher frequency of FDCs, characterized by CD21/35, MAdCAM-1, and VCAM-1 overexpression. GCs are located ectopically in Ngfr-/- mice, with lost polarization together with impaired high-affinity antibody production and an increase in circulating autoantibodies. We observe higher levels of autoantibodies in Bcl2 Tg/Ngfr-/- mice, concomitant with a higher incidence of autoimmunity and lower overall survival. Our work shows that NGFR is involved in maintaining GC structure and function, participating in GC activation, antibody production, and immune tolerance. Cell Rep . 2024 :113705. 10.1016/j.celrep.2024.113705 2211-1247 Cell reports 38307025 http://hdl.handle.net/20.500.12105/17534 NGFR regulates stromal cell activation in germinal centers.