2026-08-05T15:15:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/174902024-11-28T17:25:53Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16960
Repisalud
author
Perez-Garcia, Felipe
author
Martin-Vicente, Maria
author
Rojas-García, Rosa Lía
author
Castilla-García, Lucía
author
Muñoz-Gómez, María José
author
Hervás Fernández, Irene
author
González Ventosa, Victoria
author
Vidal-Alcántara, Erick Joan
author
Cuadros-González, Juan
author
Bermejo-Martin, Jesús F
author
Resino, Salvador
author
Martinez, Isidoro
funder
Canadian Institutes of Health Research
funder
Li Ka Shing Foundation
funder
Dalhousie Medical Research Foundation
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERES (Enfermedades Respiratorias)
funder
Junta de Castilla y León (España)
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
funder
Genome Atlantic (Canadá)
2024-02-06T07:32:43Z
2024-02-06T07:32:43Z
2022-03-15
J Infect Dis. 2022 Mar 15;225(6):977-982.
10.1093/infdis/jiab604
1537-6613
The Journal of infectious diseases
34910814
http://hdl.handle.net/20.500.12105/17490
Mucosal immune response in the upper respiratory tract is crucial for initial control of viral replication, clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and progression of coronavirus disease 2019 (COVID-19). We analyzed SARS-CoV-2 RNA load and expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2-infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in nasopharyngeal mucosa induces expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with intensive care unit admission or death, although CCL5 was the best predictor of COVID-19 severity.
eng
CCL5
COVID-19
ICU
SARS-CoV-2
Death
Gene expression
Innate immunity
Nasopharynx
Viral load
High SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severity
research article
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High_SARS-CoV-2_ViralLoad_2022.pdf
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text/plain
High_SARS-CoV-2_ViralLoad_2022.pdf.txt