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00925njm 22002777a 4500 dc Perez-Garcia, Felipe author Martin-Vicente, Maria author Rojas-García, Rosa Lía author Castilla-García, Lucía author Muñoz-Gómez, María José author Hervás Fernández, Irene author González Ventosa, Victoria author Vidal-Alcántara, Erick Joan author Cuadros-González, Juan author Bermejo-Martin, Jesús F author Resino, Salvador author Martinez, Isidoro author 2022-03-15 Mucosal immune response in the upper respiratory tract is crucial for initial control of viral replication, clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and progression of coronavirus disease 2019 (COVID-19). We analyzed SARS-CoV-2 RNA load and expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2-infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in nasopharyngeal mucosa induces expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with intensive care unit admission or death, although CCL5 was the best predictor of COVID-19 severity. J Infect Dis. 2022 Mar 15;225(6):977-982. 10.1093/infdis/jiab604 1537-6613 The Journal of infectious diseases 34910814 http://hdl.handle.net/20.500.12105/17490 CCL5 COVID-19 ICU SARS-CoV-2 Death Gene expression Innate immunity Nasopharynx Viral load High SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severity