2026-06-14T03:42:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/174872024-09-27T22:10:37Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Magro, Margarita
author
Mas-Lloret, Vicente
author
Chappell, Keith
author
Vazquez-Alcaraz, Monica
author
Cano, Olga
author
Luque, Daniel
author
Terrón-Orellana, Maria Carmen
author
Melero, Jose Antonio
author
Palomo-Sanz, Concepcion
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
2024-02-05T16:57:42Z
2024-02-05T16:57:42Z
2012-02-21
Proc Natl Acad Sci USA. 2012 Feb 21;109(8):3089-94.
10.1073/pnas.1115941109
1091-6490
Proceedings of the National Academy of Sciences of the United States of America
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286924/pdf/pnas.201115941.pdf
22323598
http://hdl.handle.net/20.500.12105/17487
Human respiratory syncytial virus (hRSV) is the most important viral agent of pediatric respiratory infections worldwide. The only specific treatment available today is a humanized monoclonal antibody (Palivizumab) directed against the F glycoprotein, administered prophylactically to children at very high risk of severe hRSV infections. Palivizumab, as most anti-F antibodies so far described, recognizes an epitope that is shared by the two conformations in which hRSV_F can fold, the metastable prefusion form and the highly stable postfusion conformation. We now describe a unique class of antibodies specific for the prefusion form of this protein that account for most of the neutralizing activity of either a rabbit serum raised against a vaccinia virus recombinant expressing hRSV_F or a human Ig preparation (Respigam), which was used for prophylaxis before Palivizumab. These antibodies therefore offer unique possibilities for immune intervention against hRSV, and their production should be assessed in trials of hRSV vaccines.
eng
Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention
research article
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