2026-04-29T07:25:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/174812024-09-27T08:05:17Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Nakamura, Kazuto
author
Fuster, Jose J.
author
Walsh, Kenneth
2024-02-05T15:18:11Z
2024-02-05T15:18:11Z
2014-04
J Cardiol. 2014 Apr;63(4):250-9.
http://hdl.handle.net/20.500.12105/17481
24355497
10.1016/j.jjcc.2013.11.006
1876-4738
Journal of cardiology
Obesity is a risk factor for various cardiovascular diseases including hypertension, atherosclerosis, and myocardial infarction. Recent studies aimed at understanding the microenvironment of adipose tissue and its impact on systemic metabolism have shed light on the pathogenesis of obesity-linked cardiovascular diseases. Adipose tissue functions as an endocrine organ by secreting multiple immune-modulatory proteins known as adipokines. Obesity leads to increased expression of pro-inflammatory adipokines and diminished expression of anti-inflammatory adipokines, resulting in the development of a chronic, low-grade inflammatory state. This adipokine imbalance is thought to be a key event in promoting both systemic metabolic dysfunction and cardiovascular disease. This review will focus on the adipose tissue microenvironment and the role of adipokines in modulating systemic inflammatory responses that contribute to cardiovascular disease.
eng
Adipokines: a link between obesity and cardiovascular disease.
journal article
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URL
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Adipokines_ A link between J Cardiol_2014.pdf
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https://repisalud.isciii.es/bitstreams/78ed335a-8346-45c9-803e-ec2806db0d4c/download
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Adipokines_ A link between J Cardiol_2014.pdf.txt