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00925njm 22002777a 4500 dc Nakamura, Kazuto author Fuster, Jose J. author Walsh, Kenneth author 2014-04 Obesity is a risk factor for various cardiovascular diseases including hypertension, atherosclerosis, and myocardial infarction. Recent studies aimed at understanding the microenvironment of adipose tissue and its impact on systemic metabolism have shed light on the pathogenesis of obesity-linked cardiovascular diseases. Adipose tissue functions as an endocrine organ by secreting multiple immune-modulatory proteins known as adipokines. Obesity leads to increased expression of pro-inflammatory adipokines and diminished expression of anti-inflammatory adipokines, resulting in the development of a chronic, low-grade inflammatory state. This adipokine imbalance is thought to be a key event in promoting both systemic metabolic dysfunction and cardiovascular disease. This review will focus on the adipose tissue microenvironment and the role of adipokines in modulating systemic inflammatory responses that contribute to cardiovascular disease. J Cardiol. 2014 Apr;63(4):250-9. http://hdl.handle.net/20.500.12105/17481 24355497 10.1016/j.jjcc.2013.11.006 1876-4738 Journal of cardiology Adipokines: a link between obesity and cardiovascular disease.