2026-05-21T23:11:21Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/174792024-09-27T09:28:55Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Fuster, Jose J.
author
Ouchi, Noriyuki
author
Gokce, Noyan
author
Walsh, Kenneth
2024-02-05T14:38:56Z
2024-02-05T14:38:56Z
2016-05-27
Circ Res. 2016 May 27;118(11):1786-807.
10.1161/CIRCRESAHA.115.306885
1524-4571
Circulation research
27230642
http://hdl.handle.net/20.500.12105/17479
Obesity is causally linked with the development of cardiovascular disorders. Accumulating evidence indicates that cardiovascular disease is the collateral damage of obesity-driven adipose tissue dysfunction that promotes a chronic inflammatory state within the organism. Adipose tissues secrete bioactive substances, referred to as adipokines, which largely function as modulators of inflammation. The microenvironment of adipose tissue will affect the adipokine secretome, having actions on remote tissues. Obesity typically leads to the upregulation of proinflammatory adipokines and the downregulation of anti-inflammatory adipokines, thereby contributing to the pathogenesis of cardiovascular diseases. In this review, we focus on the microenvironment of adipose tissue and how it influences cardiovascular disorders, including atherosclerosis and ischemic heart diseases, through the systemic actions of adipokines.
eng
Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease.
journal article
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URL
https://repisalud.isciii.es/bitstreams/a2d532d3-7056-45ae-9548-b56c1949c447/download
File
MD5
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application/pdf
Obesity Diabetes and Cardiovascular_Circ Res_2016.pdf
URL
https://repisalud.isciii.es/bitstreams/8af1edb9-dddc-4286-8dc6-feaa509fadfa/download
File
MD5
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text/plain
Obesity Diabetes and Cardiovascular_Circ Res_2016.pdf.txt