2026-06-14T03:33:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/174492024-09-27T23:37:22Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Guzman-Fulgencio, Maria
author
Berenguer, Juan
author
Garcia-Alvarez, Monica
author
Fernandez-Rodriguez, Amanda
author
Jimenez-Sousa, Maria Angeles
author
Alvarez, Emilio
author
Micheloud, Dariela
author
López, Juan Carlos
author
Miralles, Pilar
author
Cosín, Jaime
author
Catalán, Pilar
author
Resino, Salvador
funder
Instituto de Salud Carlos III
funder
RETICS-Sida (RIS-ISCIII) (España)
funder
Fundación para la Investigación y la Prevención del Sida en España
2024-02-04T19:19:59Z
2024-02-04T19:19:59Z
2013-02
J Infect. 2013 Feb;66(2):170-8.
10.1016/j.jinf.2012.10.025
1532-2742
The Journal of infection
23103287
http://hdl.handle.net/20.500.12105/17449
Objective: To evaluate the association of IL28B polymorphisms and severity of liver disease among human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. Methods: We carried out a cross-sectional study on 223 patients. Liver biopsies were evaluated according to Metavir score. IL28B polymorphisms (rs12980275, rs8099917, rs7248668, and rs11881222) were genotyped using GoldenGate(®) assay. Results: IL28B polymorphisms were in strong linkage disequilibrium, especially the couples rs12980275/rs11881222 and rs8099917/rs7248668. For all patients, the rs12980275 A allele increased the odds for significant fibrosis (F ≥ 2) odds ratio (OR) = 1.68; p = 0.018) and more rapid fibrosis progression (FPR ≥ 0.075 fibrosis units/year) (OR = 1.64; p = 0.035), and decreased the odds for liver steatosis (OR = 0.61; p = 0.046). Furthermore, the rs8099917 T allele increased the odds for F ≥ 2 (OR = 1.93; p = 0.020), FPR ≥ 0.075 (OR = 2.08; p = 0.021), and elevated ALT (≥80 IU/l) (OR = 1.78; p = 0.048). For HCV-genotype 1 patients, rs12980275 A and rs8099917 T alleles decreased the odds for liver steatosis (OR = 0.22; p < 0.001 and OR = 0.39; p = 0.048; respectively). For HCV-genotype 3 patients, the rs12980275 A allele increased the odds for F ≥ 2 ((OR = 6.30; p = 0.012), FPR ≥ 0.075 (OR = 6.40; p = 0.025), and elevated ALT (OR = 4.12; p = 0.037); and the rs8099917 T allele also increased the odds for F ≥ 2 (OR = 7.56; p = 0.027), FPR ≥ 0.075 (OR = 50.8; p = 0.012), and elevated ALT (OR = 5.39; p = 0.043). However, we did not find significant trends in patients infected with HCV-genotype 4. Conclusion: The major alleles of IL28B (rs12980275 A, rs11881222 A, rs8099917 T, and rs7248668 G) are associated with increased odds of liver disease severity in HIV patients infected with HCV-genotype 3. In contrast, HCV-genotype 1 patients carrying the major alleles of IL28B polymorphisms had lower odds for liver steatosis.
eng
AIDS
Hepatitis C
SNPs
Liver biopsy
Fibrosis
Transaminases
IL28B polymorphisms are associated with severity of liver disease in human immunodeficiency virus (HIV) patients coinfected with hepatitis C virus
research article
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IL28B_PolymorphismsAssociated_2013.pdf
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IL28B_PolymorphismsAssociated_2013.pdf.txt