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oai:repisalud.isciii.es:20.500.12105/174452025-03-19T14:03:48Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Garcia-Alvarez, Monica author Berenguer, Juan author Guzman-Fulgencio, Maria author Alvarez, Emilio author Cosín, Jaime author Micheloud, Dariela author Jimenez-Sousa, Maria Angeles author Fernandez-Rodriguez, Amanda author Aldámiz-Echevarria, Teresa author Carrero, Ana author Miralles, Pilar author Resino, Salvador author 2012-12-15 We carried out a cross-sectional study to explore whether bacterial 16S ribosomal DNA (bactDNA) shows association with severity of liver disease among human immunodeficiency virus/hepatitis C virus coinfected patients. Patients with advanced fibrosis (F3/F4), moderate activity grade (A2/A3), and high fibrosis progression rate (FPR > 0.15) had higher values of plasma bactDNA levels than did patients without these markers of liver disease (P < 0.05). The chance of having a fibrosis stage or activity grade increased was 1.20 [95% confidence interval (CI) = 1.0 to 1.44, P = 0.045] and 1.22 (95% CI = 1.1 to 1.45, P = 0.029) times greater for every 100 copies per microliter of plasma bactDNA. Likewise, the odds of having values of FPR > 0.15 was 1.18 (95% CI = 0.98 to 1.42, P = 0.089). In addition, patients with high bactDNA levels (≥175 copies per microliter) had the highest odds of having high values of Metavir score and FPR (P < 0.05). Our data show that bacterial translocation is associated with severe liver disease among human immunodeficiency virus-infected patients with chronic hepatitis C. J Acquir Immune Defic Syndr. 2012 Dec 15;61(5):552-6. 10.1097/QAI.0b013e31826ea109 1944-7884 Journal of acquired immune deficiency syndromes (1999) 22932319 http://hdl.handle.net/20.500.12105/17445 16S rDNA Bacterial translocation Hepatitis C HIV/ AIDS Liver biopsy Bacterial DNA translocation and liver disease severity among HIV-infected patients with chronic hepatitis C