2026-05-22T00:03:14Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/174402024-10-31T11:53:46Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Morales, María
author
Martin-Galiano, Antonio Javier
author
Domenech, Mirian
author
García, Ernesto
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
2024-02-02T18:29:29Z
2024-02-02T18:29:29Z
2015-09-08
Genome Biol Evol. 2015 Sep 8;7(9):2747-61.
10.1093/gbe/evv178
1759-6653
Genome biology and evolution
26349755
http://hdl.handle.net/20.500.12105/17440
Streptococcus pneumoniae (pneumococcus) is a major human pathogen. The main pneumococcal autolysin LytA and the pneumolysin Ply are two of the bacterium's most important virulence factors. The lytA- and ply-related genes are also found in other streptococci of the Mitis group (SMG). The precise characteristics of the lytA-related-but not the ply-related-genes of SMG and their prophages have been previously described. A search of the more than 400 SMG genomic sequences available in public databases (ca. 300 for S. pneumoniae), showed Streptococcus pseudopneumoniae IS7493 to harbor four ply-related genes, two of which (plyA and plyB) have 98% identical nucleotides. The plyA homolog of S. pseudopneumoniae is conserved in all S. pneumoniae strains, and seems to be included in a pathogenicity island together with the lytA gene. However, only nonencapsulated S. pneumoniae strains possess a plyB gene, which is part of an integrative and conjugative element. Notably, the existence of a bacterial lytA-related gene in a genome is linked to the presence of plyA and vice versa. The present analysis also shows there are eight main types of plyA-lytA genomic islands. A possible stepwise scenario for the evolution of the plyA-lytA island in S. pneumoniae is proposed.
eng
Pneumococcus
Main autolysin
Pneumolysin
Streptococci of the Mitis group
Evolution
Genomic island
Insights into the Evolutionary Relationships of LytA Autolysin and Ply Pneumolysin-Like Genes in Streptococcus pneumoniae and Related Streptococci
research article
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