2026-06-14T03:39:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/174232024-11-29T14:56:59Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Pérez-Olivares, Mercedes
author
Trento, Alfonsina
author
Rodriguez-Acebes, Sara
author
González-Acosta, Daniel
author
Fernández-Antorán, David
author
Román-García, Sara
author
Martinez Garcia, Maria Dolores
author
López-Briones, Tania
author
Torroja, Carlos
author
Carrasco, Yolanda R
author
Méndez, Juan
author
Moreno de Alborán, Ignacio
funder
Ministerio de Economía y Competitividad (España)
2024-02-02T09:58:50Z
2024-02-02T09:58:50Z
2018-10
EMBO Rep . 2018;19(10):e4577
10.15252/embr.201845770
1469-3178
EMBO reports
30126925
http://hdl.handle.net/20.500.12105/17423
The Myc family of oncogenic transcription factors regulates myriad cellular functions. Myc proteins contain a basic region/helix-loop-helix/leucine zipper domain that mediates DNA binding and heterodimerization with its partner Max. Among the Myc proteins, c-Myc is the most widely expressed and relevant in primary B lymphocytes. There is evidence suggesting that c-Myc can perform some of its functions in the absence of Max in different cellular contexts. However, the functional in vivo interplay between c-Myc and Max during B lymphocyte differentiation is not well understood. Using in vivo and ex vivo models, we show that while c-Myc requires Max in primary B lymphocytes, several key biological processes, such as cell differentiation and DNA replication, can initially progress without the formation of c-Myc/Max heterodimers. We also describe that B lymphocytes lacking Myc, Max, or both show upregulation of signaling pathways associated with the B-cell receptor. These data suggest that c-Myc/Max heterodimers are not essential for the initiation of a subset of important biological processes in B lymphocytes, but are required for fine-tuning the initial response after activation.
eng
Functional interplay between c-Myc and Max in B lymphocyte differentiation.
journal article
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