2026-06-14T03:44:45Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/174232024-11-29T14:56:59Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Pérez-Olivares, Mercedes author Trento, Alfonsina author Rodriguez-Acebes, Sara author González-Acosta, Daniel author Fernández-Antorán, David author Román-García, Sara author Martinez Garcia, Maria Dolores author López-Briones, Tania author Torroja, Carlos author Carrasco, Yolanda R author Méndez, Juan author Moreno de Alborán, Ignacio author 2018-10 The Myc family of oncogenic transcription factors regulates myriad cellular functions. Myc proteins contain a basic region/helix-loop-helix/leucine zipper domain that mediates DNA binding and heterodimerization with its partner Max. Among the Myc proteins, c-Myc is the most widely expressed and relevant in primary B lymphocytes. There is evidence suggesting that c-Myc can perform some of its functions in the absence of Max in different cellular contexts. However, the functional in vivo interplay between c-Myc and Max during B lymphocyte differentiation is not well understood. Using in vivo and ex vivo models, we show that while c-Myc requires Max in primary B lymphocytes, several key biological processes, such as cell differentiation and DNA replication, can initially progress without the formation of c-Myc/Max heterodimers. We also describe that B lymphocytes lacking Myc, Max, or both show upregulation of signaling pathways associated with the B-cell receptor. These data suggest that c-Myc/Max heterodimers are not essential for the initiation of a subset of important biological processes in B lymphocytes, but are required for fine-tuning the initial response after activation. EMBO Rep . 2018;19(10):e4577 10.15252/embr.201845770 1469-3178 EMBO reports 30126925 http://hdl.handle.net/20.500.12105/17423 Functional interplay between c-Myc and Max in B lymphocyte differentiation.