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oai:repisalud.isciii.es:20.500.12105/174132024-11-29T14:12:40Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Vallespinós, Mireia author Fernández, David author Rodríguez, Lorena author Alvaro-Blanco, Josué author Baena, Esther author Ortiz, Maitane author Dukovska, Daniela author Martinez Garcia, Maria Dolores author Rojas, Ana author Moreno de Alborán, Ignacio author Campanero, Miguel R author 2011-06-15 c-Myc, a member of the Myc family of transcription factors, is involved in numerous biological functions including the regulation of cell proliferation, differentiation, and apoptosis in various cell types. Of all of its functions, the role of c-Myc in cell differentiation is one of the least understood. We addressed the role of c-Myc in B lymphocyte differentiation. We found that c-Myc is essential from early stages of B lymphocyte differentiation in vivo and regulates this process by providing B cell identity via direct transcriptional regulation of the ebf-1 gene. Our data show that c-Myc influences early B lymphocyte differentiation by promoting activation of B cell identity genes, thus linking this transcription factor to the EBF-1/Pax-5 pathway. J Immunol . 2011;186(12):6726-36 10.4049/jimmunol.1002753 1550-6606 Journal of immunology (Baltimore, Md. : 1950) 21572027 http://hdl.handle.net/20.500.12105/17413 B Lymphocyte commitment program is driven by the proto-oncogene c-Myc.