2026-06-14T03:42:59Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/174102024-11-29T21:38:19Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc D'Amico, Gabriela author Jones, Dylan T author Nye, Emma author Sapienza, Karen author Ramjuan, Antoine R author Reynolds, Louise E author Robinson, Stephen D author Kostourou, Vassiliki author Martinez Garcia, Maria Dolores author Aubyn, Deborah author Grose, Richard author Thomas, Gareth J author Spencer-Dene, Bradley author Zicha, Daniel author Davies, Derek author Tybulewicz, Victor author Hodivala-Dilke, Kairbaan M author 2009-12 Sprouting angiogenesis and lymphatic-blood vessel segregation both involve the migration of endothelial cells, but the precise migratory molecules that govern the decision of blood vascular endothelial cells to segregate into lymphatic vasculature are unknown. Here, we deleted endothelial Rac1 in mice (Tie1-Cre(+);Rac1(fl/fl)) and revealed, unexpectedly, that whereas blood vessel morphology appeared normal, lymphatic-blood vessel separation was impaired, with corresponding edema, haemorrhage and embryonic lethality. Importantly, normal levels of Rac1 were essential for directed endothelial cell migratory responses to lymphatic-inductive signals. Our studies identify Rac1 as a crucial part of the migratory machinery required for endothelial cells to separate and form lymphatic vasculature. Development . 2009;136(23):4043-53. 10.1242/dev.035014 1477-9129 Development (Cambridge, England) 19906871 http://hdl.handle.net/20.500.12105/17410 Regulation of lymphatic-blood vessel separation by endothelial Rac1.