2026-05-17T00:20:35Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/174072024-11-29T17:41:14Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Scott, Clare L
author
Gil, Jesús
author
Hernando, Eva
author
Teruya-Feldstein, Julie
author
Narita, Masako
author
Martinez Garcia, Maria Dolores
author
Visakorpi, Tapio
author
Mu, David
author
Cordon-Cardo, Carlos
author
Peters, Gordon
author
Beach, David
author
Lowe, Scott W
funder
Wellcome Trust
funder
National Cancer Center (Estados Unidos)
2024-02-01T11:28:24Z
2024-02-01T11:28:24Z
2007-03-27
Proc Natl Acad Sci U S A . 2007;104(13):5389-94.
10.1073/pnas.0608721104
0027-8424
Proceedings of the National Academy of Sciences of the United States of America
17374722
http://hdl.handle.net/20.500.12105/17407
Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the INK4a/ARF tumor suppressor locus. To determine whether CBX7 might be oncogenic, we examined its expression pattern in a range of normal human tissues and tumor samples. CBX7 was expressed at high levels in germinal center lymphocytes and germinal center-derived follicular lymphomas, where elevated expression correlated with high c-Myc expression and a more advanced tumor grade. By targeting Cbx7 expression to the lymphoid compartment in mice, we showed that Cbx7 can initiate T cell lymphomagenesis and cooperate with c-Myc to produce highly aggressive B cell lymphomas. Furthermore, Cbx7 repressed transcription from the Ink4a/Arf locus and acted epistatically to the Arf-p53 pathway during tumorigenesis. These data identify CBX7 as a chromobox protein causally linked to cancer development and may help explain the low frequency of INK4a/ARF mutations observed in human follicular lymphoma.
eng
Role of the chromobox protein CBX7 in lymphomagenesis.
journal article
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