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oai:repisalud.isciii.es:20.500.12105/174072024-11-29T17:41:14Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Scott, Clare L author Gil, Jesús author Hernando, Eva author Teruya-Feldstein, Julie author Narita, Masako author Martinez Garcia, Maria Dolores author Visakorpi, Tapio author Mu, David author Cordon-Cardo, Carlos author Peters, Gordon author Beach, David author Lowe, Scott W author 2007-03-27 Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the INK4a/ARF tumor suppressor locus. To determine whether CBX7 might be oncogenic, we examined its expression pattern in a range of normal human tissues and tumor samples. CBX7 was expressed at high levels in germinal center lymphocytes and germinal center-derived follicular lymphomas, where elevated expression correlated with high c-Myc expression and a more advanced tumor grade. By targeting Cbx7 expression to the lymphoid compartment in mice, we showed that Cbx7 can initiate T cell lymphomagenesis and cooperate with c-Myc to produce highly aggressive B cell lymphomas. Furthermore, Cbx7 repressed transcription from the Ink4a/Arf locus and acted epistatically to the Arf-p53 pathway during tumorigenesis. These data identify CBX7 as a chromobox protein causally linked to cancer development and may help explain the low frequency of INK4a/ARF mutations observed in human follicular lymphoma. Proc Natl Acad Sci U S A . 2007;104(13):5389-94. 10.1073/pnas.0608721104 0027-8424 Proceedings of the National Academy of Sciences of the United States of America 17374722 http://hdl.handle.net/20.500.12105/17407 Role of the chromobox protein CBX7 in lymphomagenesis.