2026-06-14T02:19:32Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/174022024-09-21T11:46:08Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Gironès, Núria author Carrasco-Marin, Eugenio author Cuervo, Henar author Guerrero, Néstor Adrián author Sanoja, Cristina author John, Sparrow author Flores-Herráez, Reyes author Fernández-Prieto, Lorena author Chico-Calero, Isabel author Salgado, Hugo author Carrión, Javier author Fresno, Manuel author 2007-06 Chagas disease, caused by Trypanosoma cruzi, affects several million people in Central and South America. About 30% of chronic patients develop cardiomyopathy probably caused by parasite persistence and/or autoimmunity. While several cross-reactive antibodies generated during mammal T. cruzi infection have been described, very few cross-reactive T cells have been identified. We performed adoptive transfer experiments of T cells isolated from chronically infected mice. The results showed the generation of cardiac pathology in the absence of parasites. We also transferred cross-reactive SAPA-specific T cells and observed unspecific alterations in heart repolarization, cardiac inflammatory infiltration, and tissue damage. Ann N Y Acad Sci. 2007 Jun:1107:434-44. 10.1196/annals.1381.046 0077-8923 Annals of the New York Academy of Sciences 17804572 http://hdl.handle.net/20.500.12105/17402 Role of Trypanosoma cruzi autoreactive T cells in the generation of cardiac pathology.