2026-06-14T03:54:15Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/173982024-09-27T08:27:01Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Gonzalez-Guerra, Andrés author Roche-Molina, Marta author García-Quintáns, Nieves author Sánchez-Ramos, Cristina author Martín-Pérez, Daniel author Lytvyn, Mariya author de Nicolás-Hernández, Javier author Rivera-Torres, José author Arroyo, Diego F author Sanz-Rosa, David author Bernal, Juan A author 2021-08-06 The continuous relationship between blood pressure (BP) and cardiovascular events makes the distinction between elevated BP and hypertension based on arbitrary cut-off values for BP. Even mild BP elevations manifesting as high-normal BP have been associated with cardiovascular risk. We hypothesize that persistent elevated BP increases atherosclerotic plaque development. To evaluate this causal link, we developed a new mouse model of elevated BP based on adeno-associated virus (AAV) gene transfer. We constructed AAV vectors to support transfer of the hRenin and hAngiotensinogen genes. A single injection of AAV-Ren/Ang (1011 total viral particles) induced sustained systolic BP increase (130 ± 20 mmHg, vs. 110 ± 15 mmHg in controls; p = 0.05). In ApoE-/- mice, AAV-induced mild BP elevation caused larger atherosclerotic lesions evaluated by histology (10-fold increase vs. normotensive controls). In this preclinical model, atheroma plaques development was attenuated by BP control with a calcium channel blocker, indicating that a small increase in BP within a physiological range has a substantial impact on plaque development in a preclinical model of atherosclerosis. These data support that non-optimal BP represents a risk for atherosclerosis development. Earlier intervention in elevated BP may prevent or delay morbidity and mortality associated with atherosclerosis. Int J Mol Sci. 2021 Aug 6;22(16):8448. 10.3390/ijms22168448 1422-0067 International journal of molecular sciences 34445154 http://hdl.handle.net/20.500.12105/17398 Sustained Elevated Blood Pressure Accelerates Atherosclerosis Development in a Preclinical Model of Disease.