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oai:repisalud.isciii.es:20.500.12105/173892024-09-27T08:30:30Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Sánchez-Ramos, Cristina author Tierrez, Alberto author Fabregat-Andrés, Oscar author Wild, Brigitte author Sanchez-Cabo, Fatima author Arduini, Alessandro author Dopazo, Ana author Monsalve, María author 2011-07-15 UNLABELLED Translocated in liposarcoma (TLS) is a poorly characterized multifunctional protein involved in the genotoxic response. TLS regulates gene expression at several steps, including splicing and mRNA transport, possibly connecting transcriptional and posttranscriptional events. AIMS In this study we aimed to idenfity molecular targets and regulatory partners of TLS. RESULTS AND INNOVATION Here we report that TLS transcriptionally regulates the expression of oxidative stress protection genes. This regulation requires interaction with the transcriptional coactivator peroxisome proliferator activated receptor γ-coactivator 1α (PGC-1α), a master regulator of mitochondrial function that coordinately induces the expression of genes involved in detoxification of mitochondrial reactive oxygen species (ROS). Microarray gene expression analysis showed that TLS transcriptional activity is impaired in the absence of PGC-1α, and is thus largely dependent on PGC-1α. CONCLUSION These results suggest the existence of a regulatory circuit linking the control of ROS detoxification to the coordinated cross-talk between oxidative metabolism and the cellular response to genomic DNA damage. Antioxid Redox Signal. 2011 Jul 15;15(2):325-37. http://hdl.handle.net/20.500.12105/17389 21338289 10.1089/ars.2010.3643 1557-7716 Antioxidants & redox signaling PGC-1α regulates translocated in liposarcoma activity: role in oxidative stress gene expression.