2026-05-21T23:13:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/173742024-09-28T01:41:41Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Hortelano, Sonsoles
author
González-Cofrade, Laura
author
Cuadrado, Irene
author
de Las Heras, Beatriz
funder
Instituto de Salud Carlos III
funder
Ministerio de Sanidad (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Ministerio de Educación, Cultura y Deporte (España)
2024-01-25T18:51:20Z
2024-01-25T18:51:20Z
2020-02
Biochem Pharmacol. 2020 Feb:172:113739.
10.1016/j.bcp.2019.113739
1873-2968
Biochemical pharmacology
31786260
http://hdl.handle.net/20.500.12105/17374
Increasing evidence supports NLRP3 inflammasome as a new target to control inflammation. Dysregulation of NLRP3 inflammasome has been reported to be involved in the pathogenesis of several human inflammatory diseases. However, no NLRP3 inflammasome inhibitors are available in clinic. Terpenoids are natural products with multi-target activities against inflammation. Recent studies have revealed that these compounds are capable of inhibiting the activation of NLRP3 inflammasome in several mouse models of NLRP3 inflammasome-related pathogenesis. Thus, terpenoids represent an interesting pharmacological approach for the treatment of inflammatory diseases as they are endowed with a dual mechanism of inhibition of NF-KB transcription factor and inflammasome activation, both critically involved in their anti-inflammatory effects. This work provides an overview of the current knowledge on the therapeutic potential of terpenoids as NLRP3 inflammasome inhibitors.
eng
Inflammation
NLRP3-inflammasome
Terpenoids
Current status of terpenoids as inflammasome inhibitors
review article
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URL
https://repisalud.isciii.es/bitstreams/a771d22b-daa1-481b-a16b-d9b841366379/download
File
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application/pdf
CurrentStatusTerpenoidsInflammasomeInhibitors_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/798fed7c-0744-4002-90f0-eff2392bdca3/download
File
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CurrentStatusTerpenoidsInflammasomeInhibitors_2020.pdf.txt