2026-04-29T05:37:36Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/173632024-09-27T23:55:14Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609col_20.500.12105_19617

00925njm 22002777a 4500 dc Perez-Garcia, Felipe author Vázquez-Morón, Sonia author Burgueño-García, Iván author Muñoz-Gómez, María José author Zea-Sevilla, María Ascensión author Calero, Miguel author Martinez, Isidoro author Rábano, Alberto author Resino, Salvador author 2023-04-12 In this case-control study, we evaluated the association between serum antibodies against hepatitis E virus (HEV) and central nervous system (CNS) neurodegenerative disorders (NDs) in older people with dementia. The presence of anti-HEV antibodies was related to a higher adjusted odds ratio (aOR) of having CNS NDs by neuropathological diagnosis (aOR, 2.13; P = .007) and clinical/neuropathological diagnosis (1.84; P = .02). Besides, serum anti-HEV antibodies were directly related to neuropathological injury (higher vascular pathology [aOR, 1.97; P = .006]) and higher probability of Alzheimer-type pathology (1.84; P = .02). In conclusion, the presence of anti-HEV antibodies was related to higher odds of CNS NDs and neuropathological injury in older people. J Infect Dis. 2023 Apr 12;227(7):873-877. http://hdl.handle.net/20.500.12105/17363 35759220 10.1093/infdis/jiac268 1537-6613 The Journal of infectious diseases Alzheimer Hepatitis E virus Neurodegenerative disorders Older people Seroprevalence Vascular pathology Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Study