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00925njm 22002777a 4500 dc Villatoro, Antonio J author Fernández, Viviana author Claros, Silvia author Alcoholado, Cristina author Cifuentes, Manuel author Merayo-Lloves, Jesús author Andrades, José A author Becerra, José author 2017-10-28 Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is symptomatic, mainly based on the control of lubrication and inflammation, with significant limitations. Therefore, the latest research is focused on the development of new biological strategies, with the aim of regenerating affected tissues, or at least restricting the progression of the disease, reducing scar tissue, and maintaining corneal transparency. Therapies range from growth factors and cytokines to the use of different cell sources, in particular mesenchymal stem cells, due to their multipotentiality, trophic, and immunomodulatory properties. We will review the state of the art and the latest advances and results of these promising treatments in this pathology. 10.3390/ijms18112264 1422-0067 International journal of molecular sciences http://hdl.handle.net/10668/11803 29143779 http://hdl.handle.net/20.500.12105/17343 allogenic cell therapy dry eye growth factor keratoconjunctivitis sicca lacrimal gland mesenchymal stem cell regenerative medicine Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy.