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00925njm 22002777a 4500 dc Mayorga, Cristobalina author Doña, Inmaculada author Perez-Inestrosa, Ezequiel author Fernández, Tahia D author Torres, Maria J author 2017-06-07 Drug hypersensitivity reactions have multiple implications for patient safety and health system costs, thus it is important to perform an accurate diagnosis. The diagnostic procedure includes a detailed clinical history, often unreliable; followed by skin tests, sometimes with low sensitivity or unavailable; and drug provocation testing, which is not risk-free for the patient, especially in severe reactions. In vitro tests could help to identify correctly the responsible agent, thus improving the diagnosis of these reactions, helping the physician to find safe alternatives, and reducing the need to perform drug provocation testing. However, it is necessary to confirm the sensitivity, specificity, negative and positive predictive values for these in vitro tests to enable their implementation in clinical practice. In this review, we have analyzed these parameters from different studies that have used in vitro test for evaluating drug hypersensitivity reactions and estimated the added value of these tests to the in vivo diagnosis. http://hdl.handle.net/10668/11277 http://hdl.handle.net/20.500.12105/17316 28590437 10.3390/ijms18061222 1422-0067 International journal of molecular sciences IgE T-cells allergy basophils cytokines diagnosis drug hypersensitivity immunoassays in vitro The Value of In Vitro Tests to DiminishDrug Challenges.