2026-04-29T19:34:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/173052024-09-21T18:30:47Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Morcillo, Sonsoles
author
Martín-Núñez, Gracia Mª
author
García-Serrano, Sara
author
Gutierrez-Repiso, Carolina
author
Rodriguez-Pacheco, Francisca
author
Valdes, Sergio
author
Gonzalo, Montserrat
author
Rojo-Martinez, Gemma
author
Moreno-Ruiz, Francisco J
author
Rodriguez-Cañete, Alberto
author
Tinahones, Francisco
author
García-Fuentes, Eduardo
2024-01-23T20:12:42Z
2024-01-23T20:12:42Z
2017-04-10
10.1038/srep46292
2045-2322
Scientific reports
http://hdl.handle.net/10668/11075
28393901
http://hdl.handle.net/20.500.12105/17305
Stearoyl CoA Desaturase-1 (SCD) is considered as playing an important role in the explanation of obesity. The aim of this study was to evaluate whether the DNA methylation SCD gene promoter is associated with the metabolic improvement in morbidly obese patients after bariatric surgery. The study included 120 subjects with morbid obesity who underwent a laparoscopic Roux-en Y gastric by-pass (RYGB) and a control group of 30 obese subjects with a similar body mass index (BMI) to that found in morbidly obese subjects six months after RYGB. Fasting blood samples were obtained before and at six months after RYGB. DNA methylation was measured by pyrosequencing technology. DNA methylation levels of the SCD gene promoter were lower in morbidly obese subjects before bariatric surgery but increased after RYGB to levels similar to those found in the control group. Changes of DNA methylation SCD gene were associated with the changes of free fatty acids levels (r = -0.442, p = 0.006) and HOMA-IR (r = -0.249, p = 0.035) after surgery. RYGB produces an increase in the low SCD methylation promoter levels found in morbidly obese subjects. This change of SCD methylation levels is associated with changes in FFA and HOMA-IR.
eng
Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids.
research article