2026-07-23T17:12:00Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/172982024-11-28T15:26:35Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16959

00925njm 22002777a 4500 dc Estades-Rubio, Francisco J author Reyes-Martín, Alvaro author Morales-Marcos, Victor author García-Piriz, Mercedes author García-Vera, Juan J author Perán, Macarena author Marchal, Juan A author Montañez-Heredia, Elvira author 2017-03-17 Given the wide difference in price per vial between various presentations of hyaluronic acid, this study seeks to compare the effectiveness and treatment cost of stabilized hyaluronic acid (NASHA) in a single injection with standard preparations of hyaluronic acid (HA) in five injections in osteoarthritis (OA) of the knee. Fifty-four patients with knee osteoarthritis (Kellgren-Lawrence Grade II and III) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score greater than 7, with a homogeneous distribution of age, sex, BMI, and duration of disease, were included in this study. Patients were randomized into two groups: Group I was treated with NASHA (Durolane(®)) and Group II with HA (Go-ON(®)). Patient's evolution was followed up at the 1st, 2nd, 4th, 8th, 12th, and 26th week after treatment. A statistically significant improvement in WOMAC score was observed for patients treated with NASHA versus those who received HA at Week 26. In addition, the need for analgesia was significantly reduced at Week 26 in the NASHA-treated group. Finally, the economic analysis showed an increased cost of overall treatment with HA injections. Our data support the use of the NASHA class of products in the treatment of knee OA. 10.3390/ijms18030658 1422-0067 International Journal of Molecular Sciences http://hdl.handle.net/10668/2667 28304363 http://hdl.handle.net/20.500.12105/17298 Knee osteoarthritis Hyalunonic acid Stabilized hyaluronic acid (NASHA) Inyecciones intraarticulares Masculino Mediana edad Osteoartritis de la rodilla Distribución aleatoria Viscosuplementación Costos de la atención en salud Adulto Anciano Femenino Humanos Ácido hialurónico Knee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acid