2026-07-21T20:07:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/172922024-09-22T00:15:26Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16985
Repisalud
author
Pérez-Belmonte, Luis M
author
Moreno-Santos, Inmaculada
author
Cabrera-Bueno, Fernando
author
Sánchez-Espín, Gemma
author
Castellano, Daniel
author
Such, Miguel
author
Crespo-Leiro, María G
author
Carrasco-Chinchilla, Fernando
author
Alonso-Pulpón, Luis
author
López-Garrido, Miguel
author
Ruiz-Salas, Amalio
author
Becerra-Muñoz, Víctor M
author
Gómez-Doblas, Juan J
author
de Teresa-Galván, Eduardo
author
Jiménez-Navarro, Manuel
2024-01-23T20:12:30Z
2024-01-23T20:12:30Z
2017-02-23
10.7150/ijms.17821
1449-1907
International journal of medical sciences
http://hdl.handle.net/10668/11037
28367087
http://hdl.handle.net/20.500.12105/17292
Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p
eng
Sterol regulatory element-binding proteins (SREBP)
coronary artery disease
epicardial adipose tissue
type-2 diabetes mellitus.
Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
research article