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oai:repisalud.isciii.es:20.500.12105/172922024-09-22T00:15:26Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16985

00925njm 22002777a 4500 dc Pérez-Belmonte, Luis M author Moreno-Santos, Inmaculada author Cabrera-Bueno, Fernando author Sánchez-Espín, Gemma author Castellano, Daniel author Such, Miguel author Crespo-Leiro, María G author Carrasco-Chinchilla, Fernando author Alonso-Pulpón, Luis author López-Garrido, Miguel author Ruiz-Salas, Amalio author Becerra-Muñoz, Víctor M author Gómez-Doblas, Juan J author de Teresa-Galván, Eduardo author Jiménez-Navarro, Manuel author 2017-02-23 Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p 10.7150/ijms.17821 1449-1907 International journal of medical sciences http://hdl.handle.net/10668/11037 28367087 http://hdl.handle.net/20.500.12105/17292 Sterol regulatory element-binding proteins (SREBP) coronary artery disease epicardial adipose tissue type-2 diabetes mellitus. Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.