2026-07-21T08:01:21Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/172762024-09-21T20:28:34Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16966col_20.500.12105_16969col_20.500.12105_16982
Repisalud
author
García-Foncillas, J
author
Alba, E
author
Aranda, E
author
Díaz-Rubio, E
author
López-López, R
author
Tabernero, J
author
Vivancos, A
2024-01-23T20:12:14Z
2024-01-23T20:12:14Z
2017
10.1093/annonc/mdx501
1569-8041
Annals of oncology : official journal of the European Society for Medical Oncology
http://hdl.handle.net/10668/11607
28945877
http://hdl.handle.net/20.500.12105/17276
The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. The detection of mutated circulating tumor DNA by BEAMing technology addresses this gap in care and allows these patients to receive international guideline-recommended expanded RAS testing with rapid turnaround times. Furthermore, the overall concordance between OncoBEAM RAS colorectal cancer testing and standard of care tissue testing is very high (93.3%). This article presents an overview of the clinical utility and potential applications of this minimally invasive method, such as early detection of emergent resistance to anti-epidermal growth factor receptor therapy. If appropriately implemented, BEAMing technology holds considerable promise to enhance the quality of patient care and improve clinical outcomes.
eng
EGFR
colorectal cancer
liquid biopsy
mutation testing
tumor resistance
Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: an expert taskforce review.
research article