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oai:repisalud.isciii.es:20.500.12105/172762024-09-21T20:28:34Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16966col_20.500.12105_16969col_20.500.12105_16982

00925njm 22002777a 4500 dc García-Foncillas, J author Alba, E author Aranda, E author Díaz-Rubio, E author López-López, R author Tabernero, J author Vivancos, A author 2017 The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. The detection of mutated circulating tumor DNA by BEAMing technology addresses this gap in care and allows these patients to receive international guideline-recommended expanded RAS testing with rapid turnaround times. Furthermore, the overall concordance between OncoBEAM RAS colorectal cancer testing and standard of care tissue testing is very high (93.3%). This article presents an overview of the clinical utility and potential applications of this minimally invasive method, such as early detection of emergent resistance to anti-epidermal growth factor receptor therapy. If appropriately implemented, BEAMing technology holds considerable promise to enhance the quality of patient care and improve clinical outcomes. 10.1093/annonc/mdx501 1569-8041 Annals of oncology : official journal of the European Society for Medical Oncology http://hdl.handle.net/10668/11607 28945877 http://hdl.handle.net/20.500.12105/17276 EGFR colorectal cancer liquid biopsy mutation testing tumor resistance Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: an expert taskforce review.