2026-06-14T10:39:36Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/172402024-09-27T21:39:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Jimenez-Sousa, Maria Angeles author Medrano, Luz Maria author Liu, Pilar author Almansa, Raquel author Fernandez-Rodriguez, Amanda author Gómez-Sánchez, Esther author Rico, Lucía author Heredia-Rodríguez, María author Gómez-Pesquera, Estefanía author Tamayo, Eduardo author Resino, Salvador author 2017-01 Background: IL-1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was to analyse whether IL-1B rs16944 polymorphism is associated with the onset of septic shock and death after major surgery. Materials and methods: We performed a case-control study on 467 patients who underwent major cardiac or abdominal surgery. Of them, 205 patients developed septic shock (cases, SS group) and 262 patients developed SIRS (controls, SIRS group). The primary outcome variables were the development of septic shock and death within 90 days after diagnosis of septic shock. The IL-1B rs16944 polymorphism was genotyped by Sequenom's MassARRAY platform. The association analysis was performed under a recessive genetic model (AA vs. GG/GC). Results: The frequency of septic shock was higher in patients with IL-1B rs16944 AA genotype than in patients with IL-1B rs16944 GG/AG genotype when all patients were taken into account (63·6% vs. 41·8%; P = 0·006), cardiac surgery (52·2% vs. 33·3%; P = 0·072) and abdominal surgery (76·2% vs. 50·2%; P = 0·023). However, the IL-1B rs16944 AA genotype was only associated with higher likelihood of septic shock in the analysis of all population [adjusted odds ratio (aOR) = 2·26 (95%CI = 1·03; 4·97; P = 0·042], but not when it was stratified by cardiac surgery (P = 0·175) or abdominal surgery (P = 0·467). Similarly, IL-1B rs16944 AA genotype was also associated with higher likelihood of septic shock-related death in all population [aOR = 2·67 (95%CI = 1·07; 4·97); P = 0·035]. Conclusions: IL-1B rs16944 AA genotype seems to be related to the onset of septic shock and death in patients who underwent major surgery. Eur J Clin Invest. 2017 Jan;47(1):53-62. 10.1111/eci.12702 1365-2362 European journal of clinical investigation 27859227 http://hdl.handle.net/20.500.12105/17240 Death IL-1B Major surgery Septic shock SNPs Systemic inflammatory response syndrome IL-1B rs16944 polymorphism is related to septic shock and death