2026-07-22T12:30:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/172392025-03-24T14:15:32Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Jimenez-Sousa, Maria Angeles
author
Fernandez-Rodriguez, Amanda
author
Heredia, María
author
Tamayo, Eduardo
author
Guzman-Fulgencio, Maria
author
Lajo, Carmen
author
López, Elisabeth
author
Gómez-Herreras, José I
author
Bustamante, Jesús
author
Bermejo-Martin, Jesús F
author
Resino, Salvador
funder
Instituto de Salud Carlos III
funder
Junta de Castilla y León (España)
2024-01-19T12:58:59Z
2024-01-19T12:58:59Z
2012-06
Cytokine. 2012 Jun;58(3):321-6.
10.1016/j.cyto.2012.02.017
1096-0023
Cytokine
22433249
http://hdl.handle.net/20.500.12105/17239
Background: Persistent inflammation and fibrosis have been related to active progression of renal deterioration and reduced survival of kidney transplant. The aim of this study was to determine the impact of single-nucleotide polymorphisms (SNPs) located in regions related to inflammatory and immune processes on the development of chronic renal allograft dysfunction (CRAD). Methods: A retrospective study was carried out on 276 patients who received kidney transplant (KT). SNPs were genotyped via the SNPlex platform. Statistical analysis was performed with SNPstat and regression logistic analyses were adjusted by age and gender of recipients and donors, cold ischemia time and the number of human leukocyte antigen (HLA) mismatches. Results: From 276 patients with KT, 118 were non-CRAD and 158 were CRAD. Three SNPs showed significant associations with CRAD development: rs1800471 in transforming growth factor beta 1 (TGFB1), rs5186 in angiotensin II receptor type 1 (AGTR1), and rs699947 in vascular endothelial growth factor A (VEGFA). GC genotype of rs1800471 was associated with increased odds of CRAD compared to GG genotype (OR=2.65 (95% confidence interval (CI)=1.09; 6.47), p=0.025), as well as AC and AA genotype of rs699947 assuming a dominant model (OR=1.80 (95% CI=1.02; 3.20), p=0.044). Besides, AC and CC genotypes of rs5186 were associated with reduced odds of CRAD assuming a dominant model (OR=0.56 (95% CI=0.33; 0.96), p=0.033). Conclusion: Our findings suggest that three genes related to immunity and inflammation (rs1800471, rs5186 and rs699947) are associated to susceptibility or protection to CRAD, and might have diagnostic utility in predicting the likelihood of developing CRAD.
eng
Kidney transplant
Allograft rejection
SNPs
Grow factors
Biomarkers
Genetic polymorphisms located in TGFB1, AGTR1, and VEGFA genes are associated to chronic renal allograft dysfunction
research article
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URL
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application/pdf
GeneticPolymorphismsLocatedTGFB1_AGTR1_VEGFA_2012.pdf
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https://repisalud.isciii.es/bitstreams/dc5e9f27-c7a7-44b5-855d-e806fb9d9469/download
File
MD5
dd0b601e6c6904590a30df8f5ebe7f18
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GeneticPolymorphismsLocatedTGFB1_AGTR1_VEGFA_2012.pdf.txt