2026-06-14T05:06:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/172382024-09-27T22:09:39Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Jimenez-Sousa, Maria Angeles
author
Tamayo, Eduardo
author
Guzman-Fulgencio, Maria
author
Heredia, María
author
Fernandez-Rodriguez, Amanda
author
Gómez, Esther
author
Almansa, Raquel
author
Gómez-Herreras, José I
author
Garcia-Alvarez, Monica
author
Gutiérrez-Junco, Sandra
author
Bermejo-Martin, Jesús F
author
Resino, Salvador
author
Spanish Sepsis Group (SpSG)
funder
Instituto de Salud Carlos III
funder
Junta de Castilla y León (España)
funder
Pfizer
2024-01-19T12:57:03Z
2024-01-19T12:57:03Z
2015-01
J Infect. 2015 Jan;70(1):20-9.
10.1016/j.jinf.2014.07.005
1532-2742
The Journal of infection
25043396
http://hdl.handle.net/20.500.12105/17238
Objective: To analyse whether mitochondrial DNA (mtDNA) haplogroups are associated with severe sepsis and mortality after major surgery. Methods: We performed a case-control study on 240 cardiac or abdominal surgery patients developing severe sepsis (Case-group) and 267 cardiac or abdominal surgery patients without severe sepsis and with systemic inflammatory response syndrome (SIRS, Control-group). Furthermore, a longitudinal substudy was performed for analysing the survival in septic patients. Only European white patients within the N macro-cluster were included. Results: Case-group underwent cardiac surgery had lower frequencies of cluster HV (p = 0.005) and haplogroup H (p = 0.005) and higher frequencies of cluster JT (p = 0.028) than Control-group; but no significant differences were found for abdominal surgery. Besides, both cluster HV and haplogroup H were associated with decreased odds of severe sepsis (adjusted odds ratio (aOR) = 0.45 (95%CI = 0.25; 0.82); p = 0.009 and aOR = 0.48 (95%CI = 0.26; 0.87); p = 0.015, respectively) among patients underwent cardiac surgery. In Case-group, 45.4% (109/240) patients died with a survival median of 39 (95%CI = 31.4; 46.62) days. When the clusters were examined, 41% (55/134) patients within cluster HV died versus 71.4% (10/14) patients within cluster IWX (p = 0.018). Additionally, patients within cluster IWX had an increased risk of death (adjusted hazard ratio (aHR) = 2.22; (95%CI = 1.14; 4.34); p = 0.019). Conclusions: European mitochondrial haplogroups might be related to the onset of severe sepsis in patients who underwent major cardiac surgery, but not in patients underwent major abdominal surgery. Besides, mtDNA haplogroups could have influence on mortality in septic patients.
eng
Mitochondrial haplogroups
mtDNA
Genetic polymorphism
Severe sepsis
Systemic inflammatory response syndrome (SIRS)
Survival
Mitochondrial DNA haplogroups are associated with severe sepsis and mortality in patients who underwent major surgery
research article
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Mitochondrial_DNA_HaplogroupsAssociated_2015.pdf
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Mitochondrial_DNA_HaplogroupsAssociated_2015.pdf.txt