2026-06-14T03:40:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/172362025-03-24T15:49:20Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Jimenez-Sousa, Maria Angeles
author
Berenguer, Juan
author
Fernandez-Rodriguez, Amanda
author
Micheloud, D
author
Guzman-Fulgencio, Maria
author
Miralles, P
author
Pineda-Tenor, Daniel
author
Garcia-Alvarez, Monica
author
López, J C
author
Aldámiz-Echevarria, Teresa
author
Carrero, A
author
Resino, Salvador
funder
Instituto de Salud Carlos III
funder
RETICS-Sida (RIS-ISCIII) (España)
funder
Fundación para la Investigación y la Prevención del Sida en España
2024-01-19T12:50:47Z
2024-01-19T12:50:47Z
2014-03
J Viral Hepat. 2014 Mar;21(3):189-97.
10.1111/jvh.12130
1365-2893
Journal of viral hepatitis
http://hdl.handle.net/20.500.12105/17236
Hepatitis C virus (HCV) infection is associated with insulin resistance (IR), although mechanisms leading to IR in these patients are not completely understood. The aim of this study was to evaluate the association of interleukin 28B (IL28B) and interleukin 28 receptor alpha (IL28RA) polymorphisms with IR among human immunodeficiency virus (HIV)/HCV-coinfected patients. We carried out a cross-sectional study on 203 patients. IL28B (rs8099917) and IL28RA (rs10903035) polymorphisms were genotyped by GoldenGate(®) assay. IR was defined as homeostatic model assessment (HOMA) values ≥3.00. Univariate and multivariate generalized linear models (GLM) were used to compare HOMA values and the percentage of patients with IR according to IL28B and IL28RA genotypes. In total, 32% (n = 65/203) of the patients had IR. IL28B rs8099917 TT was not significantly associated with HOMA values and IR. In contrast, rs10903035 AA was significantly associated with high HOMA values taking into account all patients (P = 0.024), as well as the subgroups of patients with significant fibrosis (P = 0.047) and infected with HCV genotype 3 (P = 0.024). Additionally, rs10903035 AA was significantly associated with IR (HOMA ≥3.00) in all patients (adjusted odds ratio (aOR) = 2.02; P = 0.034), in patients with significant fibrosis (aOR = 2.86; P = 0.039) and HCV genotype 3 patients (aOR = 4.89; P = 0.031). In conclusions, IL28RA polymorphism (rs10903035) seems to be implicated in the glucose homeostasis because AA genotype increases the likelihood of IR, but this association was different depending on hepatic fibrosis and HCV genotype.
eng
AIDS
Hepatitis C
Insulin resistance
Liver fibrosis
SNPs
IL28RA polymorphism (rs10903035) is associated with insulin resistance in HIV/HCV-coinfected patients
research article
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IL28RA_Polymorphism_rs10903035_Associated_2012.pdf
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IL28RA_Polymorphism_rs10903035_Associated_2012.pdf.txt