2026-04-27T03:43:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/172182024-09-21T12:01:31Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Kofler, Natalie M
author
Cuervo, Henar
author
Uh, Minji K
author
Murtomäki, Aino
author
Kitajewski, Jan
2024-01-17T14:20:17Z
2024-01-17T14:20:17Z
2015-11-13
Sci Rep. 2015 Nov 13:5:16449.
http://hdl.handle.net/20.500.12105/17218
26563570
10.1038/srep16449
2045-2322
Scientific reports
Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1(+/-); Notch3(-/-) mice, combined deficiency of Notch1 and Notch3 altered pericyte interaction with the endothelium and reduced pericyte coverage of the retinal vasculature. Notch1 and Notch3 were shown to cooperate to promote proper vascular basement membrane formation and contribute to endothelial cell quiescence. Accordingly, loss of pericyte function due to Notch deficiency exacerbates endothelial cell activation caused by Notch1 haploinsufficiency. Mice mutant for Notch1 and Notch3 develop arteriovenous malformations and display hallmarks of the ischemic stroke disease CADASIL. Thus, Notch deficiency compromises pericyte function and contributes to vascular pathologies.
eng
Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations.
journal article
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URL
https://repisalud.isciii.es/bitstreams/9a291718-00b1-4239-8bea-106a54c2f741/download
File
MD5
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application/pdf
Combined deficiency of Notch1 and Notch3_Sci Rep_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/e14d96e5-4781-4354-b119-19d4e687e6d8/download
File
MD5
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text/plain
Combined deficiency of Notch1 and Notch3_Sci Rep_2015.pdf.txt