2026-06-14T03:51:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/172142024-09-21T13:40:44Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Guerrero, Néstor A
author
Camacho, Mercedes
author
Vila, Luis
author
Íñiguez, Miguel A
author
Chillón-Marinas, Carlos
author
Cuervo, Henar
author
Poveda, Cristina
author
Fresno, Manuel
author
Gironès, Núria
2024-01-17T14:00:39Z
2024-01-17T14:00:39Z
2015
PLoS Negl Trop Dis. 2015 Aug 25;9(8):e0004025.
10.1371/journal.pntd.0004025
1935-2735
PLoS neglected tropical diseases
26305786
http://hdl.handle.net/20.500.12105/17214
Inflammation plays an important role in the pathophysiology of Chagas disease, caused by Trypanosoma cruzi. Prostanoids are regulators of homeostasis and inflammation and are produced mainly by myeloid cells, being cyclooxygenases, COX-1 and COX-2, the key enzymes in their biosynthesis from arachidonic acid (AA). Here, we have investigated the expression of enzymes involved in AA metabolism during T. cruzi infection. Our results show an increase in the expression of several of these enzymes in acute T. cruzi infected heart. Interestingly, COX-2 was expressed by CD68+ myeloid heart-infiltrating cells. In addition, infiltrating myeloid CD11b+Ly6G- cells purified from infected heart tissue express COX-2 and produce prostaglandin E2 (PGE2) ex vivo. T. cruzi infections in COX-2 or PGE2-dependent prostaglandin receptor EP-2 deficient mice indicate that both, COX-2 and EP-2 signaling contribute significantly to the heart leukocyte infiltration and to the release of chemokines and inflammatory cytokines in the heart of T. cruzi infected mice. In conclusion, COX-2 plays a detrimental role in acute Chagas disease myocarditis and points to COX-2 as a potential target for immune intervention.
eng
Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection.
journal article
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URL
https://repisalud.isciii.es/bitstreams/e4094cde-9474-44f7-a753-b2ca45da0bc4/download
File
MD5
134382e74a148947611ec03576976a27
15830211
application/pdf
Cyclooxygenase_2 and Prostaglandin E2_PLoS Negl Trop Dis_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/1ed14c23-fd74-43d4-8d18-86e1c8184db5/download
File
MD5
e8c5950cf077b42af124c25a3b8654e1
71414
text/plain
Cyclooxygenase_2 and Prostaglandin E2_PLoS Negl Trop Dis_2015.pdf.txt