2026-06-14T03:38:02Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/172052024-09-21T11:34:28Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Delgado, Ana C
author
Maldonado-Soto, Angel R
author
Silva-Vargas, Violeta
author
Mizrak, Dogukan
author
von Känel, Thomas
author
Tan, Kelly R
author
Paul, Alex
author
Madar, Aviv
author
Cuervo, Henar
author
Kitajewski, Jan
author
Lin, Chyuan-Sheng
author
Doetsch, Fiona
2024-01-17T12:47:34Z
2024-01-17T12:47:34Z
2021-06-11
Science. 2021 Jun 11;372(6547):1205-1209.
10.1126/science.abg8467
1095-9203
Science (New York, N.Y.)
34112692
http://hdl.handle.net/20.500.12105/17205
Quiescent neural stem cells (NSCs) in the adult mouse ventricular-subventricular zone (V-SVZ) undergo activation to generate neurons and some glia. Here we show that platelet-derived growth factor receptor beta (PDGFRβ) is expressed by adult V-SVZ NSCs that generate olfactory bulb interneurons and glia. Selective deletion of PDGFRβ in adult V-SVZ NSCs leads to their release from quiescence, uncovering gliogenic domains for different glial cell types. These domains are also recruited upon injury. We identify an intraventricular oligodendrocyte progenitor derived from NSCs inside the brain ventricles that contacts supraependymal axons. Together, our findings reveal that the adult V-SVZ contains spatial domains for gliogenesis, in addition to those for neurogenesis. These gliogenic NSC domains tend to be quiescent under homeostasis and may contribute to brain plasticity.
eng
Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain.
journal article
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URL
https://repisalud.isciii.es/bitstreams/fdb399c6-2e4e-41e0-975c-33ecada652ec/download
File
MD5
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application/pdf
Release of stem cells_Science_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/0c315554-bd27-4dbf-bb41-f37c5477950f/download
File
MD5
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text/plain
Release of stem cells_Science_2021.pdf.txt