2026-08-05T15:04:42Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/172052024-09-21T11:34:28Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Delgado, Ana C author Maldonado-Soto, Angel R author Silva-Vargas, Violeta author Mizrak, Dogukan author von Känel, Thomas author Tan, Kelly R author Paul, Alex author Madar, Aviv author Cuervo, Henar author Kitajewski, Jan author Lin, Chyuan-Sheng author Doetsch, Fiona author 2021-06-11 Quiescent neural stem cells (NSCs) in the adult mouse ventricular-subventricular zone (V-SVZ) undergo activation to generate neurons and some glia. Here we show that platelet-derived growth factor receptor beta (PDGFRβ) is expressed by adult V-SVZ NSCs that generate olfactory bulb interneurons and glia. Selective deletion of PDGFRβ in adult V-SVZ NSCs leads to their release from quiescence, uncovering gliogenic domains for different glial cell types. These domains are also recruited upon injury. We identify an intraventricular oligodendrocyte progenitor derived from NSCs inside the brain ventricles that contacts supraependymal axons. Together, our findings reveal that the adult V-SVZ contains spatial domains for gliogenesis, in addition to those for neurogenesis. These gliogenic NSC domains tend to be quiescent under homeostasis and may contribute to brain plasticity. Science. 2021 Jun 11;372(6547):1205-1209. 10.1126/science.abg8467 1095-9203 Science (New York, N.Y.) 34112692 http://hdl.handle.net/20.500.12105/17205 Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain.