2026-05-17T00:20:32Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/171982024-09-21T12:21:19Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Corral, Ricardo S
author
Guerrero, Néstor A
author
Cuervo, Henar
author
Gironès, Núria
author
Fresno, Manuel
funder
Ministerio de Ciencia y Tecnología (España)
funder
Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares)
funder
RETICS-Investigación colaborativa en Enfermedades Tropicales (RICET-ISCIII) (España)
funder
Unión Europea
funder
Comunidad de Madrid (España)
funder
Fundación Ramón Areces
funder
Agencia Española de Cooperación Internacional para el Desarrollo
2024-01-17T12:00:39Z
2024-01-17T12:00:39Z
2013
PLoS Negl Trop Dis. 2013;7(2):e2034.
10.1371/journal.pntd.0002034
1935-2735
PLoS neglected tropical diseases
23409199
http://hdl.handle.net/20.500.12105/17198
Trypanosoma cruzi, the causative agent of Chagas' disease, induces multiple responses in the heart, a critical organ of infection and pathology in the host. Among diverse factors, eicosanoids and the vasoactive peptide endothelin-1 (ET-1) have been implicated in the pathogenesis of chronic chagasic cardiomyopathy. In the present study, we found that T. cruzi infection in mice induces myocardial gene expression of cyclooxygenase-2 (Cox2) and thromboxane synthase (Tbxas1) as well as endothelin-1 (Edn1) and atrial natriuretic peptide (Nppa). T. cruzi infection and ET-1 cooperatively activated the Ca(2+)/calcineurin (Cn)/nuclear factor of activated T cells (NFAT) signaling pathway in atrial myocytes, leading to COX-2 protein expression and increased eicosanoid (prostaglandins E(2) and F(2α), thromboxane A(2)) release. Moreover, T. cruzi infection of ET-1-stimulated cardiomyocytes resulted in significantly enhanced production of atrial natriuretic peptide (ANP), a prognostic marker for impairment in cardiac function of chagasic patients. Our findings support an important role for the Ca(2+)/Cn/NFAT cascade in T. cruzi-mediated myocardial production of inflammatory mediators and may help define novel therapeutic targets.
eng
Trypanosoma cruzi infection and endothelin-1 cooperatively activate pathogenic inflammatory pathways in cardiomyocytes.
journal article
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URL
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Trypanosoma cruzi infection _PLoS Negl Trop Dis_2013.pdf
URL
https://repisalud.isciii.es/bitstreams/9cb0eb70-db62-4c1c-9cbd-f9e9e6f92060/download
File
MD5
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67023
text/plain
Trypanosoma cruzi infection _PLoS Negl Trop Dis_2013.pdf.txt