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oai:repisalud.isciii.es:20.500.12105/171842025-04-23T08:09:57Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Jimenez-Sousa, Maria Angeles author Tamayo, Eduardo author Guzman-Fulgencio, Maria author Fernandez-Rodriguez, Amanda author Heredia-Rodríguez, María author Garcia-Alvarez, Monica author Bermejo-Martin, Jesús F author Pineda-Tenor, Daniel author Ruiz-Granado, Patricia author Alvarez-Fuente, Elisa author Gómez-Sánchez, Esther author Gómez-Herreras, José I author Resino, Salvador author 2014 Mitochondrial DNA variants may contribute to differences in mitochondrial function, leading to an altered immune system. The aim of this study was to analyze the relationship between mtDNA haplogroups and the development of chronic allograft dysfunction in patients with kidney transplant. A retrospective observational study was carried out on 261 patients who received kidney transplant (114 had stable transplant and 147 patients developed chronic allograft dysfunction). DNA samples were genotyped for 14 mtDNA polymorphisms by using Sequenom's MassARRAY platform (San Diego, CA, USA). Only European white patients within the N macro-cluster were included. Patients with haplogroups V (odds ratio (OR)=0.32; p=0.037) and J (OR=0.36; p=0.038) showed lower odds for developing CRAD than patients with haplogroup H. After adjusting for the most significant variables, haplogroups V and J tended to statistical significance (p=0.091 and p=0.067 respectively). This is a preliminary study in which mtDNA haplogroups seem to be implicated in susceptibility or protection for developing chronic allograft dysfunction. Int J Med Sci. 2014 Aug 17;11(11):1129-32. http://hdl.handle.net/20.500.12105/17184 25170295 10.7150/ijms.9487 1449-1907 International journal of medical sciences Kidney transplant Allograft rejection SNPs Mitochondrial haplogroups mtDNA Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant