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Repisalud author Ramírez-López, María Teresa author Vázquez, Mariam author Bindila, Laura author Lomazzo, Ermelinda author Hofmann, Clementine author Blanco, Rosarío Noemí author Alén, Francisco author Antón, María author Decara, Juan author Arco, Rocío author Ouro, Daniel author Orio, Laura author Suárez, Juan author Lutz, Beat author Gómez de Heras, Raquel author Rodríguez de Fonseca, Fernando authoraffiliation [Ramírez-López,MT; Vázquez,M; Blanco,RN; Alén,F; Antón,M; Ouro,D; Orio,L; Gómez de las Heras,R; Rodriguez de Fonseca,F] Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain. [Vázquez,M; Decara,J; Arco,R; Suárez,J; Rodríguez de Fonseca,F] Instituto de Investigación Biomédica de Málaga (IBIMA), Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain. [Bindila,L; Lomazzo,E; Hormann,C; Lutz,B] Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany. 2024-01-16T12:16:41Z 2024-01-16T12:16:41Z 2016-11-01 10.3389/fnbeh.2016.00208 1662-5153 Frontiers in Behavioral Neuroscience http://hdl.handle.net/10668/2561 27847471 http://hdl.handle.net/20.500.12105/17167 Exposure to inadequate nutritional conditions in critical windows of development has been associated to disturbances on metabolism and behavior in the offspring later in life. The role of the endocannabinoid system, a known regulator of energy expenditure and adaptive behaviors, in the modulation of these processes is unknown. In the present study, we investigated the impact of exposing rat dams to diet restriction (20% less calories than standard diet) during pre-gestational and gestational periods on: (a) neonatal outcomes; (b) endocannabinoid content in hypothalamus, hippocampus and olfactory bulb at birth; (c) metabolism-related parameters; and (d) behavior in adult male offspring. We found that calorie-restricted dams tended to have a reduced litter size, although the offspring showed normal weight at birth. Pups from calorie-restricted dams also exhibited a strong decrease in the levels of anandamide (AEA), 2-arachidonoylglycerol (2-AG), arachidonic acid (AA) and palmitoylethanolamide (PEA) in the hypothalamus at birth. Additionally, pups from diet-restricted dams displayed reduced levels of AEA in the hippocampus without significant differences in the olfactory bulb. Moreover, offspring exhibited increased weight gain, body weight and adiposity in adulthood as well as increased anxiety-related responses. We propose that endocannabinoid signaling is altered by a maternal caloric restriction implemented during the preconceptional and pregnancy periods, which might lead to modifications of the hypothalamic and hippocampal circuits, potentially contributing to the long-term effects found in the adult offspring. eng Maternal urdernutrition Endocannabinoids Endocannabinoids Hypothalamus Hyppocampus Rat Development Metabolism Behavior Adaptación psicológica Adiposidad Ansiedad Ácidos araquidónicos Restricción calórica Endocannabinoides Metabolismo Energético Hipocampo Hipotálamo Embarazo Ratas Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring. research article