2026-05-20T03:47:28Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/171332024-09-21T23:15:45Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16975

00925njm 22002777a 4500 dc Ariza, Adriana author García-Martín, Elena author Salas, María author Montañez, María I author Mayorga, Cristobalina author Blanca-Lopez, Natalia author Andreu, Inmaculada author Perkins, James author Blanca, Miguel author Agúndez, José A G author Torres, María J author 2016-03-31 Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common cause of hypersensitivity reactions, with pyrazolones the most frequent drugs inducing selective reactions. Immediate selective hypersensitivity to pyrazolones is thought to be mediated by specific-IgE. Sensitivity of in vitro diagnostic tests is low and this may be due to the incomplete characterization of the structures involved. Here we investigated whether main metabolites of metamizole (dipyrone) in human could be involved in the immune response using the basophil activation test (BAT). We studied subjects with confirmed selective immediate hypersensitivity to metamizole and performed BAT with metamizole and its metabolites: 4-methylamino-antipyrine (MAA), 4-aminoantipyrine (AA), 4-acetylamino-antipyrine (AAA) and 4-formylamino-antipyrine (FAA). BAT results showed an increase of positive results from 37.5% to 62.5% using metamizole plus metabolites as compared with the BAT carried out only with the parent drug, demonstrating that metamizole metabolites have a role in the reaction and can induce specific basophil activation in patients with immediate hypersensitivity to this drug. Our findings indicate that pyrazolone metabolites are useful for improving the in vitro diagnosis of allergic reactions to metamizole. 10.1038/srep23845 2045-2322 Scientific reports http://hdl.handle.net/10668/9960 27030298 http://hdl.handle.net/20.500.12105/17133 Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole.