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Repisalud author Ramírez-López, María Teresa author Vázquez, Mariam author Bindila, Laura author Lomazzo, Ermelinda author Hofmann, Clementine author Blanco, Rosario Noemí author Alén, Francisco author Antón, María author Decara, Juan author Ouro, Daniel author Orio, Laura author Suarez, Juan author Lutz, Beat author Rodríguez de Fonseca, Fernando author Gómez de Heras, Raquel authoraffiliation [Ramírez-López,MT; Vázquez,M; Blanco,RN; Alén,F; Antón,M; Ouro,L; Rodríguez de Fonseca,F; Gómez de Heras,R] Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain. [Vázquez,M; Degara,J; Suarez,J; Rodríguez de Fonseca,F] Unidad de Gestión Clínica de Salud Mental, Instituto IBIMA, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain. [Bindila,L; Lomazzo,E; Hofmann,C; Lutz,B] Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany. 2024-01-16T12:15:55Z 2024-01-16T12:15:55Z 2016-01-06 10.3389/fnbeh.2015.00339 1662-5153 Frontiers in Behavioral Neuroscience http://hdl.handle.net/10668/2502 26778987 http://hdl.handle.net/20.500.12105/17121 Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypothalamic contents of arachidonic acid and the two major endocannabinoids (anandamide and 2-arachidonoylglycerol) at birth. Palmitoylethanolamide, but not oleoylethanolamide, also decreased. Additionally, pups from palatable diet-fed dams displayed lower levels of anandamide and palmitoylethanolamide in the hippocampus. The low-weight male offspring, born from palatable diet exposed mothers, gained less weight during lactation and although they recovered weight during the post-weaning period, they developed abdominal adiposity in adulthood. These animals exhibited anxiety-like behavior in the elevated plus-maze and open field test and a low preference for a chocolate diet in a food preference test, indicating that maternal exposure to a hypercaloric diet induces long-term behavioral alterations in male offspring. These results suggest that maternal diet alterations in the function of the endogenous cannabinoid system can mediate the observed phenotype of the offspring, since both hypothalamic and hippocampal endocannabinoids regulate feeding, metabolic adaptions to caloric diets, learning, memory, and emotions. eng Maternal diet Endocannabinoids Adipogenesis Anxiety Development Hypothalamus Hippocampus Adiposidad Ansiedad Ácido araquidónico Cacao Cannabinoides Dieta Emociones Endocannabinoides Etanolaminas Preferencias alimentarias Glicéridos Hipocampo Lactancia Masculino Exposición materna Madres Ácidos oléicos Ácidos palmíticos Fenotipo Alcamidas poliinsaturadas Ratas Destete Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Adiposity and Anxiety-Like Behaviors in Male Rat Offspring. research article