2026-08-29T12:56:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/171112024-09-21T20:05:25Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
García-Vilas, Javier A
author
Martínez-Poveda, Beatriz
author
Quesada, Ana R
author
Medina, Miguel Ángel
2024-01-15T18:17:59Z
2024-01-15T18:17:59Z
2015-12-22
10.3390/md14010001
1660-3397
Marine drugs
http://hdl.handle.net/10668/9679
26703630
http://hdl.handle.net/20.500.12105/17111
Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies.
eng
(+)-aeroplysinin-1
angiogenesis
cancer
inflammation
marine drugs
sponges
Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
research article